|
KMID : 1189419930060010053
|
|
Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
1993 Volume.6 No. 1 p.53 ~ p.70
|
|
|
Effect of Taklee Hwangki Tang Extract on Inflammation
|
|
Kang Shung-Won
Roh Seok-Seon
|
|
|
Abstract
|
|
|
|
These experiments were conducted to investigate the effect of Taklee Hwangki Tang(THT) on inflammation. THT extract did not affected on the leakage of evans blue into peritoneal cavity and mouse paw edema induced by histamine, but decreased the cottom pellet granuloma formation. Using proliferation of Balb/c 3T3 fibroblast cell line as an in vitro model of granulation tissue formation, the ability of THT to stumulate cellular proliferation of fibroblast cells was investigated. When the cells were seeded at 1×10^4 cells/well, balb/c 3T3 cells are reached to the late expponential phase at 3rd day. Under the conditions established above, THT increased the proliferation of Balb/c 3T3 cells at concentration of 10^- ,10^-6 and 10^-5 g/ml. The treatment of 10^-6 g/ml of THT did not influence onthe NDA syntesis and proteinsynthesis of the cells. The 10% serum from THT treated mice(500mg/kg/day for 4 days) increased the proliferation of Balb/c 3T3 fibroblast markedly, but decreased the DNA synthesis and protein sythesis of the cells. The results suggest that THT may be of practical therapeutic use at the period of the last in. flammation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|